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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRNE
All Species:
28.48
Human Site:
S374
Identified Species:
69.63
UniProt:
Q04844
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04844
NP_000071.1
493
54697
S374
S
P
P
R
R
A
S
S
V
G
L
L
L
R
A
Chimpanzee
Pan troglodytes
Q5IS76
494
56903
G373
G
S
D
A
V
P
R
G
L
A
R
R
P
A
K
Rhesus Macaque
Macaca mulatta
XP_001097094
493
54680
S374
S
P
P
R
R
A
S
S
V
G
L
L
L
R
A
Dog
Lupus familis
XP_536608
492
54288
S374
P
P
P
R
R
A
S
S
V
G
L
L
L
R
A
Cat
Felis silvestris
Mouse
Mus musculus
P20782
493
54896
S374
S
P
A
R
R
A
S
S
V
G
I
L
L
R
A
Rat
Rattus norvegicus
P09660
494
54930
S374
S
P
A
R
R
A
S
S
V
G
I
L
L
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P02713
514
58907
S376
Q
A
T
R
R
R
S
S
L
G
L
M
V
K
A
Frog
Xenopus laevis
P49580
504
57770
S376
P
R
E
R
R
R
S
S
L
G
I
M
L
K
A
Zebra Danio
Brachydanio rerio
NP_996947
518
60339
S380
A
L
P
R
R
S
S
S
L
G
Y
I
A
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P09478
567
64001
T373
D
Q
P
P
E
V
L
T
D
V
Y
H
L
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
35.8
95.9
87
N.A.
88.6
87.6
N.A.
N.A.
52.9
52.5
43.4
N.A.
32
N.A.
N.A.
N.A.
Protein Similarity:
100
54.2
97.3
92.6
N.A.
93
92.1
N.A.
N.A.
68.2
71
61.7
N.A.
50.6
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
46.6
46.6
46.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
73.3
73.3
80
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
20
10
0
50
0
0
0
10
0
0
10
10
80
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
0
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
10
0
80
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
30
10
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
10
% K
% Leu:
0
10
0
0
0
0
10
0
40
0
40
50
70
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
20
50
50
10
0
10
0
0
0
0
0
0
10
10
10
% P
% Gln:
10
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
10
0
80
80
20
10
0
0
0
10
10
0
50
0
% R
% Ser:
40
10
0
0
0
10
80
80
0
0
0
0
0
0
0
% S
% Thr:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
10
10
0
0
50
10
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _